AmoyDx® HRR Liquid NGS Panel
NGS
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The AmoyDx® HRR Liquid NGS Panel is a next-generation sequencing (NGS)-based assay intended for the qualitative detection of single nucleotide variants (SNVs) and insertions and deletions (InDels) in the protein-coding regions and intron/exon boundaries of 25 genes, including ATM, ATR, BARD1, BRCA1, BRCA2, BRIP1, CDK12, CHEK1, CHEK2, ESR1, FANCA, FANCL, HDAC2, MLH1, MRE11, NBN, PALB2, RAD51B, RAD51C, RAD51D, RAD54L, PIK3CA, PTEN, AKT1, and AR, using circulating cell-free DNA (cfDNA) isolated from plasma derived from anti-coagulated peripheral whole blood specimens. In addition, the assay also allows the detection of PTEN copy number losses.
Liquid Biopsy Complement Tissue Biopsy in Prostate and Breast Cancer
Comprehensive Coverage of Actionable Biomarkers: mCRPC and BC
Mutations( Hover over each mutational type to highlight genes covered )
All
ATM
ATM
SNV/INDELS
ATR
ATR
SNV/INDELS
BARD1
BARD1
SNV/INDELS
BRCA1
BRCA1
SNV/INDELS
BRCA2
BRCA2
SNV/INDELS
BRIP1
BRIP1
SNV/INDELS
CDK12
CDK12
SNV/INDELS
CHEK1
CHEK1
SNV/INDELS
CHEK2
CHEK2
SNV/INDELS
FANCA
FANCA
SNV/INDELS
FANCL
FANCL
SNV/INDELS
HDAC2
HDAC2
SNV/INDELS
MLH1
MLH1
SNV/INDELS
MRE11
MRE11
SNV/INDELS
NBN
NBN
SNV/INDELS
PALB2
PALB2
SNV/INDELS
PIK3CA
PIK3CA
SNV/INDELS
RAD51B
RAD51B
SNV/INDELS
RAD51C
RAD51C
SNV/INDELS
RAD51D
RAD51D
SNV/INDELS
RAD54L
RAD54L
SNV/INDELS
PTEN
PTEN
CNV
SNV/INDELS
AKT1
AKT1
SNV/INDELS
AR
AR
SNV/INDELS
ESR1
ESR1
SNV/INDELS
Specifications
Kit format
24 reactions/kit
Sample type
Plasma cfDNA
Instrument
Illumina NovaSeq 6000, NextSeq 500, NextSeq 550, NextSeq 550Dx (RUO mode), MiSeq, MiSeqDx (RUO mode), MiniSeq, Salus Pro
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