AmoyDx® HANDLE OncoHeme NGS Panel
NGS
Inquiry
The AmoyDx® HANDLE OncoHeme NGS Panel is a next generation sequencing based in vitro diagnostic device intended for the qualitative detection of single nucleotide variants (SNVs), insertions and deletions (InDels), gene fusions, and other structural variants (SVs), including FLT3 internal tandem duplications (FLT3-ITDs) and KMT2A partial tandem duplications (KMT2A-PTDs), in 59 genes associated with hematologic malignancies, using DNA and RNA isolated from bone marrow or peripheral whole blood specimens
This comprehensive coverage includes 59 genes and 424 fusion pairs
Mutations( Hover over each mutational type to highlight genes covered )
All
ABL1
ABL1
FUSIONS
SNV/INDELS
ASXL1
ASXL1
SNV/INDELS
BCOR
BCOR
SNV/INDELS
BRAF
BRAF
SNV/INDELS
CALR
CALR
SNV/INDELS
CBFB
CBFB
FUSIONS
SNV/INDELS
CBL
CBL
SNV/INDELS
CEBPA
CEBPA
SNV/INDELS
CREBBP
CREBBP
FUSIONS
SNV/INDELS
CSF3R
CSF3R
SNV/INDELS
CTCF
CTCF
SNV/INDELS
DIS3
DIS3
SNV/INDELS
DNMT3A
DNMT3A
SNV/INDELS
ETV6
ETV6
SNV/INDELS
ETV7
ETV7
FUSIONS
EZH2
EZH2
SNV/INDELS
FBXW7
FBXW7
SNV/INDELS
FLT3
FLT3
ITD
SNV/INDELS
GATA1
GATA1
SNV/INDELS
GATA2
GATA2
SNV/INDELS
IDH1
IDH1
SNV/INDELS
IDH2
IDH2
SNV/INDELS
IKZF1
IKZF1
SNV/INDELS
JAK2
JAK2
FUSIONS
SNV/INDELS
JAK3
JAK3
SNV/INDELS
KIT
KIT
SNV/INDELS
KMT2A
KMT2A
FUSIONS
PTD
SNV/INDELS
KRAS
KRAS
SNV/INDELS
MAX
MAX
SNV/INDELS
MEN1
MEN1
SNV/INDELS
MLLT10
MLLT10
FUSIONS
MPL
MPL
SNV/INDELS
MYC
MYC
SNV/INDELS
MYD88
MYD88
SNV/INDELS
NF1
NF1
SNV/INDELS
NPM1
NPM1
FUSIONS
SNV/INDELS
NRAS
NRAS
SNV/INDELS
NUP214
NUP214
FUSIONS
NUP98
NUP98
FUSIONS
SNV/INDELS
PDGFRA
PDGFRA
FUSIONS
SNV/INDELS
PHF6
PHF6
SNV/INDELS
PPM1D
PPM1D
SNV/INDELS
PTPN11
PTPN11
SNV/INDELS
RAD21
RAD21
SNV/INDELS
RARA
RARA
FUSIONS
RB1
RB1
SNV/INDELS
RIT1
RIT1
SNV/INDELS
RUNX1
RUNX1
FUSIONS
SNV/INDELS
SETBP1
SETBP1
SNV/INDELS
SF3B1
SF3B1
SNV/INDELS
SRSF2
SRSF2
SNV/INDELS
STAG2
STAG2
SNV/INDELS
STIL
STIL
FUSIONS
TCF3
TCF3
FUSIONS
TET2
TET2
SNV/INDELS
TP53
TP53
SNV/INDELS
U2AF1
U2AF1
SNV/INDELS
UBTF
UBTF
SNV/INDELS
WT1
WT1
SNV/INDELS
ZRSR2
ZRSR2
SNV/INDELS
Specifications
Sample type
Bone Marrow, whole blood
Alterations detected
SNVs, InDels, Fusions, FLT3-ITD, KMT2A-PTD
Sequencer
Illumina MiSeq, MiSeq Dx, NextSeq 500, NextSeq 550, NextSeq 550Dx, NovaSeq 6000, Salus Pro
Inquiry