The AmoyDx® HANDLE HRR NGS Panel facilitates the detection of somatic and germline variants across 27 genes within the Homologous Recombination Repair (HRR) pathway, along with 5 tumor driver genes.
Mutations( Hover over each mutational type to highlight genes covered )
BRCA1
BRCA2
AR
ATM
ATR
BARD1
BRIP1
CDH1
CDK12
CHEK1
CHEK2
ESR1
FANCA
FANCL
HDAC2
HOXB13
MRE11
NBN
PALB2
PPP2R2A
PTEN
RAD51B
RAD51C
RAD51D
RAD54L
STK11
TP53
BRAF
ERBB2
KRAS
NRAS
PIK3CA
Secure data analysis and interpretation
Detection of SNV, InDel and germline LR for BRCA1/BRCA2
Fast turnaround time and cost-effective
Streamlined one-tube workflow
Specifications
5 driver genes (BRAF, ERBB2, KRAS, NRAS, PIK3CA): hotspot regions
Publications
1. Chi, K.N. et al. Niraparib plus abiraterone acetate with prednisone in patients with metastatic castration-resistant prostate cancer and homologous recombination repair gene alterations: second interim analysis of the randomized phase III MAGNITUDE trial. Annals of Oncology, Volume 34, Issue 9, 772 - 782.
2. Liu Y, Jin B, Shen C, Gao X, Qi X, Ma M, Li H, Hao H, Tang Q, Yang K, Mi Y, Guan J, Feng X, He Z, Li H and Yu W (2023) Somatic and germline aberrations in homologous recombination repair genes in Chinese prostate cancer patients. Front. Oncol. 13:1086517.
3. Liu H, Zhang Z, Chen L, Pang J, Wu H and Liang Z (2022) Next-Generation Sequencing Reveals a Very Low Prevalence of Deleterious Mutations of Homologous Recombination Repair Genes and Homologous Recombination Deficiency in Ovarian Clear Cell Carcinoma. Front. Oncol. 11:798173.
4. Xingran Jiang, Xiumei Hu, Yajuan Gu, Yunlong Li, Mulan Jin, Hongying Zhao, Ruixia Gao, Zhan Huang, Jun Lu. Homologous recombination repair gene mutations in Chinese localized and locally advanced prostate cancer patients. Pathology - Research and Practice, Volume 224, 2021, 153507.