C-KIT Mutation Detection Kit
PCR
Real-time PCR Assays
Product Description

C-KIT Mutation Detection Kit

The AmoyDx C-KIT Mutation Detection Kit is a sensitive and selective assay for the detection of the D816V mutation in the C-KIT gene.

KIT is a receptor tyrosine kinase (RTK) that normally plays a critical role in hematopoiesis. Mutation of the KIT gene leads to aberrant growth signaling in the cell harboring the mutant protein. KIT mutations have been associated with several malignancies, including acute myeloid leukemia (AML), gastrointestinal stromal tumors (GIST), and testicular carcinomas. The most common mutation of KIT in these disorders is a substitution of the aspartic acid residue in position 816 with a valine (D816V), leading to constitutive activation of the receptor.

Technological Principles:

The C-KIT mutation detection kit employs a real-time PCR format combined with patented technology- “mutation specific amplification technology” - to detect mutations in DNA samples. The method is much more specific and sensitive than alternative technologies such as DNA sequencing.

Testing Procedure
Compatible Sample Types:FFPE Samples
Compatible Real-time PCR Instrument
ABI 7500
ABI 7900HT
ABI StepOnePlus
Bio-Rad CFX96
LightCycler 480 II
Stratagene Mx3000P™
Other Info.

To order, please contact sales@amoydx.com.

AmoyDx C-KIT Mutation Detection Kit provides reagents to perform assays for 24 tests:

 Product Name

 Size (test/kit)

 Storage

 Cat. No.

 C-KIT Mutation Detection Kit (Bulk)

 24T

 -20℃

8.01.20701X024E

*   For Research Use Only

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