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JAK2 Mutation Detection Kit

JAK2 Mutation Detection Kit

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JAK2 Mutation Detection Kit

    The JAK family of non-receptor tyrosine kinases, includes JAK1, JAK2, JAK3, and TYK2. Growth factors and cytokines can regulate gene transcription through JAK-dependent activation of signal transducer and activator of transcription (STAT). The JAK-STAT signal transduction pathway regulates cell proliferation, differentiation, apoptosis and immune regulation. Activation of JAK2 by mutation of the amino acid at position 617 (V617F ) is associated with myeloproliferative disorders, including polycythemia vera (mutations found in 90% of cases), essential thrombocythemia (50%) and idiopathic myelofibrosis (50%). JAK2 mutation is the main diagnostic indicator of MPD. The ADx JAK2 V617F Mutation Detection Kit is a highly selective and sensitive assay for detecting the V617F mutation in the  JAK2 oncogene. AmoyDx’s patented technology allows detection of 1% mutant DNA in a background of 99% normal DNA, while ensuring that false negatives are minimized.  The procedure is easilyadapted for use in high-throughput sample processing.

     

    Breaking JAK2 News: The JAK2 V617F mutation was found in three of 24 lung cancer samples using deep exome sequenicing. If this discovery is validated it will represent a major new driver mutation in lung cancer, with the added benefit that the mutant kinase is inhibited by well-studied drugs such as gefitinib. 

    Lipson, D., et al. Nature Medicine, 8:3, p382. 13 Feb 2012.

    Intended Use: 
    For research purpose use only. This kit is used to detect the JAK2 V617F mutation in the DNA samples.
     
    Technological Principles: 
    The JAK2 mutation kit is a real-time PCR assay. It employs mutation-specific primers and aJAK2 V617F -targeted proprietary fluorescent probe to detect low-copy number (1%) JAK2V617F-mutant DNA in cancer tissue. 

     

    Key Features and Benefits:
    Simple Procedure —— only one step required for sample application, results could be obtained within 90minutes;
    • High sensitivity and accuracy —— can detect1% of mutant in a background of wild type genomic DNA;
    • Leading technology—— employs AmoyDx’s proprietary technologies-“mutation specific amplification technology”, which is compatible with world-leading technologies;
    • Easy Standardization—— general PCR lab could perform, technicians could obtain reproducible results without special training, which facilitate standardized management;
    • Reliable product quality—— Produced in GMP plant, quality management systems has passed Chinese CFDA and ISO13485.

    Sample type: blood.
     
    Customer Service Hotline: 86-592-6806835
    Email:Sales@amoydx.com


  • Contact Now

To order, please contact Sales@amoydx.com.
AmoyDx JAK2 Mutation Detection Kit provides reagents to perform assays for 24 tests:

 

 Product Name

 Size (test/kit)

Storage

 Cat. No.

 JAK2 Mutation Detection Kit

 24T

 -20℃

 ADx-JA01

               *   For Research Use Only
 

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