EML4-ALK Fusion Gene Detection Kit

EML4-ALK Fusion Gene Detection Kit

  • Item No :ADx-AE01, ADx-AE02
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EML4-ALK Fusion Gene Detection Kit

    The AmoyDx EML4-ALK Fusion Gene Detection Kit is a sensitive and selective assay for the detection of the twenty-one most common fusion transcripts of the chimeric EML4-ALK gene.


    The EML4-ALK fusion oncogene represents one of the newest molecular targets in non-small-cell lung cancer (NSCLC). First described in 2007, the fusion results from a small inversion within chromosome 2p. This inversion leads to expression of a chimeric tyrosine kinase having the N-terminal half of echinoderm microtubule-associated protein-like 4 (EML4) fused to the intracellular kinase domain of anaplastic lymphoma kinase (ALK). The EML4-ALK protein possesses potent oncogenic activity both in vitro and in vivo. This activity can be blocked by small-molecule inhibitors, supporting a role for EML4-ALK as a key driver of lung tumorigenesis.


    Intended Use: 
    CE marked for IVD use in Europe and CFDA approved for clinical use in China.
    Technological Principles: 
    The EML4-ALK kit employs proprietary real-time PCR technology to detect the twenty-one most common EML4-ALK fusion transcripts. RNA that has been purified from the FFPE tissue is first reverse transcribed to cDNA with RT enzyme supplied with the kit. The EML4-ALK fusion cDNAs are then specifically amplified with cross-junction PCR primers and quantitatively detected with fluorescent probes.


    Key Features and Benefits:

    • Simple Procedure — only one step required for sample application, results obtained within 90 minutes.

    • ADx-ARMs technology — employs a patented two-step PCR amplification procedure and novel fluorescent probe design.
    • Easy Standardization — any general PCR lab can perform the test, and technicians obtain reproducible results without specialized training.
    • Reliable product quality — Produced in a dedicated GMP plant, with quality management systems that have passed Chinese SFDA and international ISO13485 standards.

    • Sample type: FFPE tissue.

    Customer Service Hotline: 86-592-680-6835

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AmoyDx EML4-ALK Fusion Gene Detection Kits are available in the following size, minimum order of 12 tests:


 Product Name

Size (tests/kit) 


 Ref. No.

 EML4-ALK Fusion Gene Detection Kit





  EML4-ALK Fusion Gene Detection Kit





                 see the FAQs page for an explanation of "pre-loaded" and "bulk" kits.

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